Focus on Pharmacogenomics and Pharmacogenetics: Health Sciences Library

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PharmGKB: The Pharmacogenetics and Pharmacogenomics Knowledge Base

"PharmGKB is a publicly available Internet research tool developed by Stanford University with funding from the National Institutes of Health (NIH) and is part of the NIH Pharmacogenetics Research Network (PGRN), a nationwide collaborative research consortium. Its aim is to aid researchers in understanding how genetic variation among individuals contributes to differences in reactions to drugs."

NCBI Entrez Databases via PubMed

The National Center for Biotechnology Information maintains more than 15 databases of use to molecular biologists, geneticists, and others researching genetic and protein sequences. These include the RefSeq and GenBank DNA/RNA depositories, the Protein Data Bank, dbSNP, and the Conserved Domains Database. Please see the library's NCBI Entrez Global Search Portal guide for brief itemDescs of the major offerings.

Nucleic Acids Research Molecular Biology Database Collection

Every January the journal Nucleic Acids Research collates, indexes, and summarizes new or revised databases available for research in molecular biology, genetics, genomics, and proteomics. The total list of databases is free and online in the MBDC.

Websites

National Institute of General Medical Sciences: Research Funding: Pharmacogenetics Research Network

"The Pharmacogenetics Research Network (PGRN) is a nationwide collaboration of scientists studying the effect of genes on people's responses to a wide variety of medicines." This site conatins links to the research network proper as well as other communities, funding opportunities, news and hot topics discussions, and various other resources for researchers.

Pharmacogenomics: Medicine and the New Genetics

This site is aimed more at the consumer or neophyte than at the researcher in pharmacogenomics, and thus provides some nice overviews of the premises of pharmacogenomics, benefits and ethical issues, and "barriers to progress." A nice collection of links to more resources at the end of the page leads to more resources appropriate (primarily) for nonscientists.

Journal Articles

PubMed (MEDLINE)

PubMed, a service of the National Library of Medicine, includes over 14 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

International Pharmaceutical Abstracts

International Pharmaceutical Abstracts is produced by the American Society of Health-System Pharmacists and includes information from over 750 pharmaceutical, medical, and health-related journals published worldwide since 1970. The database covers the entire spectrum of drug therapy and pharmaceutical information so researchers such as toxicologists, those in cosmetic companies, medical librarians and health practitioners can easily locate the answers to any drug-related problems that they encounter. Topics covered include information on biopharmaceutics & pharmacokinetics, new drug delivery systems, pharmacist liability, legal, political & ethical issues, and many others. Examples of titles covered in IPA include: America's Pharmacist (USA), American Journal of Health-System Pharmacy (USA), British Medical Journal (England), Clinical Drug Investigation (New Zealand), Clinical Pharmacokinetics (New Zealand), International Journal of Clinical Pharmacology and Therapeutics (Germany), International Journal of Pharmaceutical Compounding (USA), International Journal of Pharmaceutics (Netherlands), etc. A unique feature of abstracts included for clinical studies is the inclusion of the study design, number of patients, dosage, dosage forms, and dosage schedule. (Source: vendor website.)

BIOSIS (BasicBIOSIS)

BasicBIOSIS covers 350 of the basic core of life science journals most easily found in college and university libraries. These journals were chosen because they are written for non-biology majors and can be easily understood by undergraduates. The database includes popular science titles not covered in other BIOSIS databases. BasicBIOSIS is a specialized database created for FirstSearch subscribers. This database is copyrighted by Biological Abstracts Inc. (BIOSIS).

BasicBIOSIS contains references from virtually every life science discipline, including: agriculture, biochemistry, biology, biotechnology, botany, ecology, environment, genetics, medicine, microbiology, neuroscience, nutrition, physiology, and public health. (Source: vendor website.)

Selected Electronic Journals:

The library has a wide selection of journals available for your use, both in print and electronically. The titles selected below are specifically focused on pharmacogenomics and genetics. Many general genetics and human genetics/genomics journals are also available electronically. Please search the Catalog for print journals and the E-Journal Finder for electronic journals.

Books & Other Publications

Search the UNC-Chapel Hill Catalog for books and reference materials.

Search Tip: The MeSH term for this topic are "Pharmacogenetics". Try searching for this term under "subject heading" in the catalog to see the panoply of what's available!

Browse the Collection: The primary call number area for books about pharmacogenetics is QV 38. However, you may find information on these specific topics elsewhere in the collection:

Eugenics - HQ 750
Genetics - QH 426-470
Psychopharmacology - QV 77

Drug Resistance - QW 45
Pharmacoepidemiology - QZ 42
Medical Genomics - QZ 50

Selected E-books and E-Book Collections:

The NCBI Bookshelf has a number of genetics and molecular biology textbooks that may contain information on pharmacogenetics/genomics, drug design and discovery, and other topics of interest. Search using keywords.

NetLibrary is a large collection of electronic books, including quite a few on drug discovery and design. Search for books using your specific topic or "drug design" for best results.

Eurekah Bioscience Collection (Landes Bioscience, 2003 - via NCBI) - Includes a chapter on drug design.

STAT!Ref - This collection includes Basic & Clinical Pharmacology.