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Evidence Based Practice
The evidence-based practice movement teaches clinicians,
nurses, and pharmacists to gather and evaluate the best available scientific evidence applicable to the particular case they are treating,
and to apply that evidence in the proven best way. For pharmacists this includes ensuring that processes for prepration, dosing,
adminstration, and outcomes assessment are error-free. Evidence-based pharmacotherapy involves careful review of the drug literature,
including meta-analyses of drug effectiveness, risk estimations, outcomes evaluation, and cost-benefit analyses.
 The scientific base of evidence based medicine particularly relies upon clinical trials, particularly over-view or
meta-analyses of outcome trials which have used drugs belonging to the same or closely related
pharmacological classes.
The Health Sciences Library has created the self-paced Introduction
to Evidence-Based Medicine tutorial for health care practitioners or students who need a basic introduction to the principles
of evidence based medicine. An introduction to the basic resources used in EBM is available from the
NC AHEC EBM Education Center
of Excellence module.
Online Resources
Cochrane Library UNC Access ONLY
The Cochrane Collaboration is an international organization that aims to help people make
well informed decisions about healthcare by preparing, maintaining and
promoting the accessibility of systematic reviews of the effects of healthcare interventions. Within the
Cochrane Library is the database of Systematic Reviews, the database of Abstracts of Reviews of
Effectiveness, the Cochrane Controlled Trials Register, the Cochrane Methodology Register,
the Health Technology assessment database, and the NHS Economic evaluation database.
PubMed
"PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical
articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed
includes links to many sites providing full text articles and other related resources." EBM researchers may find the
Clinical Queries search feature (under "Pubmed Services" on the left-hand navigation bar) of use.
Searching tutorial available.
HSTAT (Health Services/Technology Assessment Text)
A freely accessible database which provides access to the full-text of documents useful in health care decision making.
HSTAT includes: clinical practice guidelines, quick-reference guides for clinicians, consumer brochures, and evidence reports
sponsored by the Agency for Health Care Policy and Research (AHCPR); AHCPR technology assessment reports; National
Institutes of Health (NIH) consensus development conference and technology assessment reports, and other materials.
National Guideline Clearinghouse
This site is a public resource for evidence-based clinical practice guidelines. NGC is sponsored by the
Agency for Healthcare Research and Quality (formerly the Agency for Health Care Policy and Research) in
partnership with the American Medical Association and the American Association of Health Plans.
Therapeutics Initiative: Evidence Based Drug Therapy
The Therapeutics Initiative was established in 1994 by the Department of Pharmacology and
Therapeutics in cooperation with the Department of Family Practice at the University of British
Columbia to provide physicians and pharmacists with up to date, evidence based, practical information
on rational drug therapy.
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