This question is too general. We want information on specific drug therapies."); write(""); } fenster.document.close(); } function q2() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
This is a well-built clinical question. We know our patient population (children with strep throat), our intervention (amoxicillin), the comparison (penicillin), and the outcome we want to achieve (relief of symptoms)."); write(""); } fenster.document.close(); } function q3() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
Better for what? We need to know the illness or condition (patient problem) that is being treated."); write(""); } fenster.document.close(); } function q4() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
This search would retrieve citations that use the words STREP and THROAT in the title or abstract. Many of these would not necessarily be about amoxicillin, children, or penicillin. Limiting these to review articles will retrieve general overview articles."); write(""); } fenster.document.close(); } function q5() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
This search would retrieve many irrelevant articles. The fatal flaw is using OR instead of AND for the drugs. This retrieves many articles that discuss either one of the drugs, in addition to articles that compare the 2 drugs."); write(""); } fenster.document.close(); } function q6() { fenster = open("", "Anzeige", "width=200,height=350"); fenster.document.open(); with (fenster.document) { i++; write("
This strategy includes all the important concepts - sore throat (pharyngitis), streptococcus, amoxicillin and penicillin. It's a therapy question so we want to find a clinical trial (publication type) in a pediatric population."); write(""); } fenster.document.close(); } function q7() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
Under PATIENTS AND METHODS it clearly states that patients were randomly assigned using a table of random numbers to receive either penicillin or amoxicillin."); write(""); } fenster.document.close(); } function q8() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
Usually this information can be found in a methods section, which describes how the study was carried out. Go back and reread the PATIENTS AND METHODS section."); write(""); } fenster.document.close(); } function q9() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
The study started with 161 patients. 9 patients were excluded from the final analysis for various reasons that are stated. Of the 152 that continued the study, all 152 returned for follow-up evaluations at 4 to 6 days and/or 14 to 21 days. See RESULTS."); write(""); } fenster.document.close(); } function q10() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
The RESULTS section provides detailed information about the disposition of the 161 patients selected for this study."); write(""); } fenster.document.close(); } function q11() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
The 152 patients that returned for follow-up were analyzed within their groups. However we need to account for the 9 patients who were excluded from the study results and whether or not this will have an impact on the data. (See Figure 1 and Table 1)"); write(""); } fenster.document.close(); } function q12() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
Aside from the 9 patients excluded from the study, the remaining 152 patients were analyzed within their groups. However we need to account for the 9 patients who were excluded from the study results and whether or not this will have an impact on the data. (See Figure 1 and Table 1)"); write(""); } fenster.document.close(); } function q13() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
The physician was blinded to the study. However it is not clear that the patient was really BLIND to the treatment because the drugs were not administered identically. For this study blinding the patient may not be that important. See PATIENTS AND METHODS."); write(""); } fenster.document.close(); } function q14() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
The clinician was blinded to the study. It is not clear that the patient was really BLIND to the treatment because the drugs were not administered identically. This may not be important because outcomes were measured by laboratory culture, not by patient feedback."); write(""); } fenster.document.close(); } function q15() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
The groups were similar with respect to age, sex and duration of illness before treatment. See the RESULTS section."); write(""); } fenster.document.close(); } function q16() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
Go back to the RESULTS section and review the first paragraph."); write(""); } fenster.document.close(); } function q17() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
It appears that during the study they were treated the same."); write(""); } fenster.document.close(); } function q18() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
There is no mention of different treatment during the study period. If at the end, patients still have active cases of GABHS they were given penicillin."); write(""); } fenster.document.close(); } function q19() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
Overall this study appears to be methodologically sound. There were no major problems. The next step is to review the results of the study."); write(""); } fenster.document.close(); } function q20() { fenster = open("", "Anzeige", "width=200,height=300"); fenster.document.open(); with (fenster.document) { i++; write("
There are no major flaws with this study. It does appear to be methodologically sound. You should now look at the results."); write(""); } fenster.document.close(); } function close() { fenster.document.close(); }