Introduction
Welcome! This tutorial is designed to help you improve your PubMed searching skills.
It covers:
- entering basic searches;
- revising searches to find more of the relevant literature;
- focusing search results using Limits;
- selecting and downloading PubMed article references
- finding the complete article online or in print
PubMed is a free web based interface for searching MEDLINE
- Created by the National Library of Medicine
-
Covering medicine, nursing, dentistry, veterinary medicine, the health care system, and preclinical sciences
- Containing information about articles, many with detailed abstracts, from 4,600 journals in 30 languages (does not include information about meeting abstracts, conference proceedings, dissertations, patents, or websites)
- Using Medical Subject Headings (MeSH) index terms
- Dating back to 1950 with the inclusion of OLDMEDLINE
- Linking to some electronic full-text at publishers's websites
UNC-CH Students, faculty and staff should connect through a UNC-CH website in order see links to UNC Full Text Online.

On the UNC Dentistry homepage go to 'Quick Links' at the bottom of the page and select Library Resources.

PubMed contains information about journal articles. When you search PubMed you are searching this information, not the full-text of the article. Here are the pieces of information that make up a PubMed record.
Abbreviated journal title; Date;Vol # (Issue #):
Page #s
|
J Am Dent Assoc.
2001 Mar;132
(3):
368-76.
|
Link(s) to comments |
Comment in:
- J Am Dent Assoc. 2001 Jun;132(6):728.
|
Link to full-text article |
 |
Title of the article |
Evaluation of a bioadhesive device for the management of aphthous ulcers. |
Author's names |
Kutcher MJ, Ludlow JB, Samuelson AD, Campbell T, Pusek SN. |
First author's institutional affiliation |
Department of Diagnostic Sciences and General Dentistry, University of North Carolina School of Dentistry, CB 7450 Brauer Hall, Chapel Hill, N.C. 27599-7450, USA. MJKUTCHE@email.unc.edu |
Detailed abstract
|
BACKGROUND: Aphthous ulcers are common and painful. Current treatments are
palliative and focused on pain reduction. This article reports on the clinical
trials of a novel, bioadhesive treatment modality. METHODS: Formulations of
2-octyl cyanoacrylate, or 2-OCA, tissue adhesive were tested in two blinded,
sham-controlled studies. A total of 200 patients with a single, painful aphthous
ulcer were entered. In the first study, the investigators applied the tissue
adhesive to the aphthous ulcers; in the second trial, the subjects themselves
applied the tissue adhesive to their ulcers. The authors evaluated the safety,
pain reduction and healing times associated with the bioadhesive. RESULTS: The
bioadhesives were found to be safe with no significant adverse events. The
short- and long-term pain reduction achieved with an investigator-applied
adhesive was significant compared with that achieved with a sham device (P =
.024 and P = .036, respectively). The investigator-applied adhesive also
demonstrated a significant reduction in healing time over the sham device (P =
.021). In the definitive trial, in which the subjects themselves applied the
tissue adhesive, pain reduction with a predicate device approved by the U.S.
Food and Drug Administration and with the bioadhesive was significantly better
than with a sham application (P < .05). The active devices were not statistically different from each other (P = .37). No difference in healing time was evident between devices and the sham. CONCLUSIONS: The formulations of 2-OCA tissue adhesives tested were safe and demonstrated statistically significant pain reduction when applied by either the investigators or the subjects. CLINICAL IMPLICATIONS: Our clinical trials indicate that these novel tissue adhesives could be used as nonprescription, over-the-counter devices to provide significant pain relief for patients suffering from aphthous ulcers.
|
Publication Types |
- Clinical Trial
- Clinical Trial, Phase I
- Clinical Trial, Phase II
- Multicenter Study
- Randomized Controlled Trial
|
MeSH Terms |
- Administration, Topical
- Adult
- Comparative Study
- Cyanoacrylates/administration & dosage
- Cyanoacrylates/therapeutic use*
- Drugs, Non-Prescription/administration & dosage
- Drugs, Non-Prescription/therapeutic use
- Female
- Human
- Hydrogel/administration & dosage
- Hydrogel/therapeutic use
- Linear Models
- Male
- Pain/prevention & control
- Pain Measurement
- Placebos
- Proportional Hazards Models
- Safety
- Self Administration
- Single-Blind Method
- Statistics, Nonparametric
- Stomatitis, Aphthous/drug therapy*
- Support, Non-U.S. Gov't
- Support, U.S. Gov't, P.H.S.
- Time Factors
- Tissue Adhesives/administration & dosage
- Tissue Adhesives/therapeutic use*
- Wound Healing
|
Substance terms: |
- Cyanoacrylates
- Drugs, Non-Prescription
- Placebos
- Tissue Adhesives
- Hydrogel
- octyl 2-cyanoacrylate
|
Grant Support |
|
Unique PMID # |
PMID: 11258094 [PubMed - indexed for MEDLINE] |
Tutorial Contents Basic Searches
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