Searching the Literature for Animal Testing Alternatives

Steps in the Research Process

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Construct the Query

Select & Search Databases

Evaluate Your Search

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Specialized Alternatives Databases

Databases that contain materials specifically relevant to the reduction, refinement, and replacement of animals in laboratory research and teaching will be of particular utility to your literature search. These databases have been created and are maintained by a variety of groups, including the U.S. government, universities in the U.S. and abroad, and private research institutes. You will find that these databases will cover a broader range of publication formats than commercial databases, including videotapes and software packages in addition to peer-reviewed articles.

ALTBIB: Bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing - U.S. National Library of Medicine Specialized Information Services
"The intent of the bibliography is to assist in identifying methods and procedures helpful in supporting the development, testing, application, and validation of alternatives to the use of vertebrates in biomedical research and toxicology testing. This bibliography is produced from MEDLARS database searches, performed and analyzed by subject experts from the Toxicology and Environmental Health Information Program (TEHIP) of the Specialized Information Services Division (SIS) of the National Library of Medicine (NLM)." Search help available.

AltWeb Pain Management Database - Johns Hopkins Center for Alternatives to Animal Testing
"This database includes information about anesthesia and analgesia for most commonly used laboratory animals, including: rats, mice, primates, dogs, cats, rabbits, pigs, guinea pigs, birds, sheep, fish, and exotic species. It provides information about available drugs and the side effects of commonly used drugs. Citations are from publications that have published laboratory animal studies or human clinical studies with relevance to animal research." The database contains over 10,000 records, and is updated quarterly using records from MEDLINE, TOXLINE, AGRICOLA, and AGRIS.

ICCVAM / NICEATM Test Method Evaluations - NIH Interagency Coordinating Committee on the Validation of Alternative Methods & The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods
Included are fewer than ten alternative test methods that have been submitted to ICCVAM for review and evaluation. They contain "information about the reviews of these tests, the respective categories of toxicity, and/or the ICCVAM Working Group assigned to the assays."

INVITRODERM: Alternatives to Skin Irritation / Corrosion Testing in Animals
"This not-for-profit website has been developed to display information about alternatives to skin irritation / corrosion testing in animals. The site currently contains approximately 360 abstracts about this topic from peer-reviewed scientific journals. Nothing has been published here without the permission of the appropriate publisher or author."

NORINA: Norwegian Inventory of Alternatives - The Norwegian Reference Centre for Laboratory Animal Sciences & Alternatives
"NORINA (A Norwegian Inventory of Alternatives) provides information on over 3500 audiovisual aids and other alternatives such as computer programs to the use of animals or animal products in teaching, at all levels from junior [elementary] school to university." Search help available.

NCA: Netherlands Centre Alternatives to Animal Use Database
"The NCA database comprises 3Rs research projects. These projects were originally funded by the Dutch Platform on Alternatives to Animal Experiments. Currently, these projects are funded by the Programme committee on Alternatives to Animal Experiments of the Dutch Health and Research Council."

Refinement and Enrichment for All Laboratory Animals Database - Animal Welfare Institute
"This information resource is a merger of two databases on refinement & enrichment for non-primate and primate laboratory animals. It disseminates reference material on all aspects of refinement of housing and handling conditions and environmental enrichment for all animals kept in research, testing and teaching institutions. Refinement is the attempt to enhance animal welfare and control extraneous variables that may increase research data variability. Environmental enrichment is the provision of stimuli that promote the expression of species-appropriate behavioral and mental activities. This database comprises published articles, abstracts, book chapters, books, photos, and videotapes. Entries have been read/screened and annotated by the authors to guarantee their relevance to the topic." Search help available.

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